I think, Most of the domainers, traffic seekers, internet marketers have tried safelists and have experienced that they get nothing except Huge Junks of mails in their inbox for the amount they have paid.
Most of these safelist providers also have an ad in their site "Tired of full email boxes. Schedule your email box to delete emails every hour without logging to email account using automated email deletion script for any email account " and provide us an email (for some money of course) which will delete all incoming mails at frequent intervals!.
So you are paying to send mails/ads which gets auto deleted or deleted by the users themselves without even seeing the subject.
So if you are new to internet marketing,
"Never go for safelist. They are not effective"
The second point is, we always love to send mails only to prospective buyers, But in safelists you send mails only to similar web marketers like you which is less or not at all effective. NO ordinary people(People who are not web marketers) joins safelists.
Only internet marketers, online business men, MLM seekers joins the safelist.
This means, its a group where everyone are marketers!
So better stay away from safelists.
Never pay money to recieve junk mails.