I've found that Auslogic's defragger works wonders on machines running AVG, which really fragments the hell of of countless files. And, on two machines with MSE, it's never failed to defrag any MSE files.
Like you, I almost always have a gazillion going on at any given moment on any machine that I'm on. And, unlike some other AV apps, I've yet to find MSE to be a hindrance.
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