You must be able to. Blat runs on windows systems like asp does.
Blat is a Win32 command line utility that sends eMail using the SMTP or NNTP protocols.
http://www.blat.net/?faq/index.html
What are you wanting to use blat for?
I know I am not much help here, but thought I could get the ball rolling.
The best I can see is here :
http://www.aspin.com/home/tutorial/email
and use one of the tutorials or examples and apply it to blat.
Here is an example, it doesn't specifically refer to blat, but applies to using asp to call email programs:
http://www.brainjar.com/asp/formmail/
Sorry, don't know if I have been any help, but I like to get stuff started and learn a bit in the process :O)
Never know if new ideas are spawned, either.