Hi zenhead,
The site navigates well (except the logo/header should link to the homepage) and loads quickly.
I think you should have more copy on the front page that explains what the make-a-wish foundation is. I already knew, from ads I'd heard on internet radio, but others might not.
For me the highlight of your site is the stories about the kids who have received their wishes. Could you put more of that on the front page -- more pictures and quotes from their stories?
I think that would be the best way to promote the cause.
Also, consider aligning the links along the left side there -- centered looks funny. Buttons would be nice too, but wouldn't really fit with the site. Your site reminds me of
http://www.w3.org/ with all of its textiness. Look at what they did to organize their site and consider doing something like that with yours, to better emphasize and differentiate your sections.
Thanks for the submission! I look forward to what everyone else thinks.
Garrett