Dear Kate,
One of the sites I work on focusses on Feng Shui. We have a .co.uk domain but we are actually international... although we have a.com domain too, the .co.uk preceeded it by a couple of years and so has better
PR and hence is the main URL we use. We have a UK registered office because we operate there as a limited company and so it is a legal requirement, but our staff are now based in Vancouver, Canada and operate worldwide. I don't know how you feel about that, but we have decent listings on most engines and respectable traffic figures from an audience closely akin to yours. Have a look and see what you think.
Our addy is
http://www.rising-dragon.co.uk.
Warm regards,
Dani x