Do you really want the highest clickthrough ratio? Who is clicking through? Sometimes you are better putting your price or qualifying information in the ad so that only qualified people clickthrough. Google does not care if your prospects are qualified they just want people to click. I have had very targetted campaigns banned from Google because the clickthrough ratio was too low. Of course, they never tell you that they say that you keywords are of low quality. But if your site is a site about dog food and nothing but dog food and your keyword is dog food and they give you a quality score of 1 you know something is not right. Google want high clickthroughs. But do you?

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