SmartPPC EVO seems to be what you’re looking for. The ad serving software with understandable interface allows to build advertising business. SmartPPC EVO enables you to combine several ad sources on your sites: get your own advertisers registered, display ads from Google, YPN and others, additionally, ads from XML feeds like Miva, Looksmart and others.

You’ll have full control over your advertisers and ad-sources. The system is supposed to be a professional solution for traffic monetization.