I agree - no popups under any circumstances.
But with regard to mixing the ads in with the content - try a proper split test for a decent period of time - to see what the difference is in revenue before deciding that you definitely do not want ads mixed in with your content (if it is 300% different - you my change your mind...
Having said that, if your site is fairly new - it will be easier to get people to link to it, and increase its popularity with much less intrusive adverts..
Good luck.