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When your bodega makes as much per square foot as Walmart, I'll be the first one at the seminar they hold. I'm all for studying what converts, that's the point.
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If you're all for studying what converts, then you wouldn't have made this statement. There are different purposes, different niches, and different strategies depending on the goals of the website. Not everyone aspires to be Walmart (thank GOD!) And yes, as carlos_p said, paying attention to the science of ergonomics, and as Andilinks said, seeing what works within the type of similar site to what you're aiming for (or, like Amazon did, blazing the path and inventing the new tools that work) are part of that.
Dcrux, you said, "What I am talking about are ecommerce patterns that are a level beyond simple usability. I'm talking about a simple CSS change that produces a 389% increase in response. Not a word of text changed, mind you -- pure design." If indeed you are the holder of that secret, why don't you let us be the judges of how effective it can and will be on sites other than the one you used it on? Let's hear it.
Side note-- carlos_p, if you've never read "Cheaper by the Dozen" as a school age kid, you might get a kick out of it. We who grew up in nearby towns had it as required reading in school early on. It's a very entertaining book about how the science of Ergonomics was invented.