Our site is CSS except for some of the info that is tabular data. It takes time, but a lot easier to maintain, especially if something happens to me. I've had to maintain sites done with Tables and it takes a lot of time just to figure out the structure.

Margins and padding are a big difference. The simpler it is, the more likely it is to look correct in all major browsers.

Since I grow up with IE, that is where I start. Once I have the layout I start testing in both. IE does offer conditionals and like others said, there is lots of info out there on fixing the various things that don't work.

CSS offers you the ability to basically go
Header
Column
Column
Footer

Or almost whatever you like. We do use a small amount of Javascript for the menus, but it wasn't necessary, just made the pages cleaner.

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