I absolutely agree with Sands.
If you want an excellent contrast and luminosity, then try using as background color instead of #ffffff, use #f1f1f1 and for foreground color (font color) instead of #999999, use #474747.
Then you have a perfect combination for color blind people and for people with dyslexia too.
About your font sizes I have some tips but I will let you know if you first fix the above issue.
And if you really do all that, then I will give you many more tips about your site.
Your site has a great potential with very little work, to become one of the best sites on the web.
It!s up to you. :)
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