Autographs has a point about the 2 domains being on the same server. If being blocked for spam is your concern use different servers. But then again, why do you foresee being blocked for spam??? Do you plan on spamming? NOT a good idea, no matter what domains/servers you use.
Creating a sub-domain also works to keep things separate (newsletter.yoursite.com) Google likes sub-domains and, unless they changed algorythms again, rate your main site higher when you have a sub-domain or 3.
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