I prefer to design with fixed-width elements, especially in regard to text. Text that spans an entire wide-screen laptop, for instance, is much too hard to read (it's easy to get lost when moving your eye down to the next line, it's even easier to leave the website).
I'm a control freak when it comes to design and layout, which is why I prefer a fixed layout. You can fool the visitor by filling the screen with color and graphics while keeping the content at a manageable size for reading and navigating.
I also prefer designs that center the content instead of layouts that are positioned off to the left with empty space filling the right. Those types of sites feel lopsized to me.
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