I have an elderly neighbor who had this problem. To top it off, he's Italian and speaks broken English. He asked me to look at his computer and sure enough his toolbar had been hijacked by a porn portal and his home page had been changed. He was getting daily porn come-ons in his email and every now and then nice photo would show up unannounced on his desktop. The first thing I did was to clear all his cookies and, reset the home page and turn off the toolbar, but no dice. It still came up every time I restarted IE. So I decided to download Ad-Aware. Every time I tried to go to Lavasoft, IE crashed. If I tried Google or Altavista, IE crashed. Not only wouldn't this program go away, it wouldn't let me download anti-spyware or use a different search engine! So I went back to my house, downloaded Ad-Aware, burned it onto a CD and brought it back to his house. Had to reboot the computer -- the program was running off a DLL in his Windows directory -- but I eventually got rid of the program. He still gets lots of spam for Viagra and, er, equipment enlargers, but that's another problem.